Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: a PRCT.
نویسندگان
چکیده
BACKGROUND & AIMS : We hypothesize that wound closure in trauma patients with disorders in wound healing is accelerated by supplementation of antioxidant micronutrients and glutamine. METHODS In a randomized, double-blind, placebo-controlled trial, 20 trauma patients with disorders in wound healing were orally supplemented with antioxidant micronutrients (ascorbic acid, α-tocopherol, β-carotene, zinc, selenium) and glutamine (verum) or they received isoenergetic amounts of maltodextrine (placebo) for 14 days. Plasma/serum levels of micronutrients, glutamine, and vascular endothelial growth factor-A (VEGF-A) were determined before and after supplementation. In the wound, several parameters of microcirculation were measured. Time from study entry to wound closure was recorded. RESULTS Micronutrients in plasma/serum did not change except for selenium which increased in the verum group (1.1 ± 0.2 vs. 1.4 ± 0.2 μmol/l; P = 0.009). Glutamine decreased only in the placebo group (562 ± 68 vs. 526 ± 55 μmol/l; P = 0.047). The prevalence of hypovitaminoses and the concentration of VEGF-A did not change. Considering microcirculation, only O(2)-saturation decreased in the placebo group (56.7 ± 23.4 vs. 44.0 ± 24.0 [arbitrary units]; P = 0.043). Wound closure occurred more rapidly in the verum than in the placebo group (35 ± 22 vs. 70 ± 35 d; P = 0.01). CONCLUSIONS Time to wound closure can be shortened by oral antioxidant and glutamine containing supplements in trauma patients with disorders in wound healing.
منابع مشابه
Outcomes and Complications of Primary Closure of Wounds in the War Wounded Referred to a Hospital in Tehran in 2017
Background and Aim: In most studies, in the treatment of war wounds, debridement and delayed wound healing have been suggested and there has been no emphasis on initial wound closure. The aim of this study was to determine the outcomes and complications of primary closure of wounds in war-wounded referred to a hospital in Tehran, Iran. Methods: In this cross-sectional study, 102 war-wounded wit...
متن کاملWound dressing of second degree burn by chamomile cream and Silver sulfadiazine cream; the effects on wound healing duration; a triple blind RCT
Background: Burn is the fourth most prevalent trauma around the world that many people are affected by it every year. One of the common methods of healing burn wounds is the use of Silver sulfadiazine cream 1%, the most important complication of which is the delay in healing of the wound. Objective: This study was done in order to identify and evaluate effective drugs in the treatment of burn w...
متن کاملمقایسه عوارض روش دوختن در یک لایه و در چند لایه زخم پا پس از برداشتن ورید صافن بزرگ در بای پس کرونر
Background and purpose: Cardiovascular diseases is the leading cause of death in the world. Over the last decades, open heart surgery reduced the mortality rate of these patients. The long saphenous vein is most commonly-used conduit in coronary artery bypass surgery. Complications associated with its harvest can lead to significant patient morbidity. We aimed to determine the optimal method...
متن کاملLocal Administration of L-Arginine Accelerates Wound Closure
Objective(s) The process of wound healing involves tightly integrated events including inflammation, granulation tissue formation and remodeling. Systemic administration of L-arginine promotes wound healing but its global side effects are undesirable. To confine the action of L-arginine at the site of injury, we tested the effects of local administration of L-arginine on the healing of excisio...
متن کاملWound Healing Activity of Mimusops elengi Leaves
In the present investigation, methanolic extract of Mimusops elengi leaves were evaluated for wound healing activity. Entire wound healing process is complex series of events that begins at the moment of injury and can continue for months to years. Methanolic extract of Mimusops elengi leaves were examined for wound healing activity in the form of ointment by the excision, the incision and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical nutrition
دوره 31 4 شماره
صفحات -
تاریخ انتشار 2012